Schmidler research group


NEW : Postition available: Postdoctoral Researcher in Computational Structural Biology and Immunology


Welcome to the Schmidler research group web page. Members of the group do theoretical and applied research in Bayesian statistics, bioinformatics, and computational biology. Ongoing projects in the areas of proteomics, molecular simulation, single-molecule experiments, protein folding, and prediction of protein structure and function are described under Biology Projects. Our work on Monte Carlo algorithms, change-point and segmentation problems, statistical shape theory and datamining may be found under Statistics Projects. In addition, we have projects on computer-aided drug design and biomaterials through various collaborations.

Scott Schmidler is Assistant Professor of Statistics and Decision Sciences at Duke University. Members of the group come from graduate and postdoctoral programs throughout the University and Medical Center, including Statistics, Mathematics, Computer Science, Engineering, and Biochemistry, as well as the Bioinformatics and Genome Technology program. Group resources include a shared 96-processor Beowulf cluster. Students interested in opportunities for rotation within the lab should send inquiries to scs@stat.

For inquiries from students outside Duke, please see Information for prospective students and postdocs.


Current projects in the group organized by biological area or by statistical methodology:

Biology

Statistics

Protein Folding Stochastic Segmentation
Proteomics Statistical Shape Theory
Protein Structure Prediction Monte Carlo Algorithms
3D Structure Analysis and Function Prediction



This page is still under construction (and now badly out of date). Please check back later.




Protein Structure Prediction

Bayesian structure prediction

Group members
Collaborators Doug Brutlag - Biochemistry Department, Stanford University
Jun Liu - Statistics Department, Harvard University
Project Description
Publications Schmidler SC, Liu JS, Brutlag DL (2001)
Bayesian protein structure prediction
Case Studies in Bayesian Statistics, Vol. 5, pp 363-378.

Schmidler, SC, Liu, JS, Brutlag, DL (2000)
Bayesian segmentation of protein secondary structure
J. Comp. Biol., Vol 7, No 1/2, pp 233-248.




Protein Folding

Helix-coil transitions

Group members Jen-hwa Chu, Jeff Krause
Collaborators Terry Oas - Biochemistry Department, Duke University
Project Description
Publications


Ab-initio Folding

Group members Ben Cooke
Collaborators
Project Description
Publications




Proteomics

Peptide Mass Fingerprinting and Mass Spectrometry

Group members Casper Wu
Collaborators Tim Haystead - Pharmacology and Cancer Biology, Duke University
Mike Datto - Pathology, Duke University
Project Description
Publications




3D Structure Analysis and Function Prediction

Protein Structure Alignment

Group members
Collaborators
Project Description
Publications Wu, TD, Schmidler, SC, Hastie, T, Brutlag, DL (1998)
Regression analysis of multiple protein structures
J. Comp. Biol., Vol 5, No 3, pp 597-607.
(preprint version with color figures)

Wu, TD, Schmidler, SC, Hastie, T, Brutlag, DL (1998)
Modeling and superposition of multiple protein structures using affine
transformations: analysis of the globins

Pacific Symposium on Biocomputing '98 507-518
(color version)




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Scott Schmidler's home page