Syllabus -- STA790
Case Studies in Cancer Molecular and Genetic Epidemiology

Abstract

This course centers on case studies from cancer clinical and genetic epidemiology in which the research objective is to elucidate the role that environmental determinants and inherited genetic variation play in cancer etiology and biology and/or to characterize relationships between variation in the tumor genome and epigenome and disease heterogeneity, prognosis and etiology. Case studies will be chosen so as to provide both a broad sampling of active areas of inquiry into the molecular and genetic epidemiology of cancer and of the statistical methods upon which these fields rely. Each will provide a platform for comparing established methods, for surveying active streams of methodological research and for highlighting opportunities for development of novel Bayesian techniques. The case studies will provide the student with hands-on experience managing, exploring and modeling high dimensional molecular genetics data sets; utilizing bioinformatic resources in the design, analysis and interpretation of studies of genetic and genomic data; and the opportunity to develop and test novel analytic approaches.

Prerequisites

Stat 601 (290) and Stat 611 (213) or equivalent or instructor's consent.

Strong R skills recommended.

Structure

The typical class will comprise a short lecture on background material and a presentation of (part of) a case study separated by a short break. Instructor and students will take turns in presenting their analyses of case study data sets; in some cases these may be interactive, but in most will take the form of a presentation to a hypothetical collaborator on the project under discussion.

Syllabus

Date	Lecture Topic	Case Study	References
Jan 10
Jan 17	No Class	(Out-of-Town)
Jan 24
Jan 31
Feb 7
Feb 14
Feb 21
Feb 28
Mar 7
Mar 14
Mar 21
Mar 28
Apr 4
Apr 11
Apr 18$^\dagger$
Apr 25	No Class
May 2	No Class	Exam Week

$^\dagger$ Reading Period. Make-up day for 1/17/12 class.

Resources

General
Tag	Description	Use	URL
NCI	National Cancer Institute	Info	http://www.cancer.gov/cancertopics
	Dictionary of Cancer Terms	Info	http://www.cancer.gov/dictionary
The TCGA:	The Cancer Genome Atlas	Data	http://cancergenome.nih.gov/
Genetics
Tag	Description	Use	URL
NCI Cancer Genetics	National Cancer Institute	Info	http://www.cancer.gov/cancertopics/genetics
	Dictionary of Genetic Terms	Info	http://www.cancer.gov/geneticsdictionary
Cancer Risk
Tag	Description	Use	URL
NCI Risk Prediction	Risk Modeling Resources	Info	http://epi.grants.cancer.gov/cancer_risk_prediction/
Functional Genomics
Tag	Description	Use	URL
Epigenetics
Tag	Description	Use	URL

Notes

No References!

About this document ...

Syllabus -- STA790
Case Studies in Cancer Molecular and Genetic Epidemiology

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